equivalent doses of ace inhibitors chart

Reference 539 540 1. 50mg. The combination may increase the risk of angioedema. Monitoring of the renal function and serum potassium is needed to reduce the incidence of renal insufficiency and hyperkalaemia … ENTRESTO is contraindicated in patients with a history of angioedema related to previous angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) therapy. Eprosartan (Teveton®) 600mg. 10 (AHRQ Pub. Titrate over a period of a few days or weeks, May give once daily or in two divided doses, Consider starting dose of 2.5 mg if adding to a diuretic, If CrCl is ≤ 30 ml/min, starting dose is 2.5 mg once daily, Lower starting doses may be appropriate in patients taking diuretics, CrCl 10 - 30 ml/min - start with half the recommended starting dose. All ACE inhibitors require titration to effect over the same timeframe. If CrCl < 30 ml/min, then starting dose is 5 mg daily. Food decreases absorption. If this happens you might try an arb. ACE inhibitors and ARBs share indications, contraindications and most side effects (except cough, more frequent with ACE inhibtors). Enalapril. ACE to ARB Conversion Table Angiotensin Receptor Blocker (ARB) Dose Conversion Drugs Low Dose Medium Dose High Dose losartan (Cozaar) 125. Appendix A: Dosage information on proton pump inhibitors. This mechanism is responsible for the rare but potentially serious adverse effect of UTIs and other genital infections. Approximate Dose Equivalence. ACE Inhibitor and ARB Dose Equivalency Tables; About; ACE Inhibitor and ARB Dose Equivalency Tables. Pharmacist's Letter/Prescriber's Letter 2009;25(8):250801. Captopril 12.5 – 150mg daily (in 2 or 3 divided doses) Enalapril 2.5 – 40mg daily Fosinopril 5 – 40mg daily Lisinopril 2.5 – 40mg daily Perindopril 2 – 8 mg daily Quinapril 2.5 – 40mg daily Ramipril 1.25 – 10mg daily Trandolapril 0.5 – 4mg daily 3: Cardiovascular Therapeutic Guidelines, 2003. Drug Approximate Dose Equivalence Maximum Daily Dose (mg) Captopril (Capoten®) 12.5 mg tid: 150: Enalapril maleate (Vasotec®) 5 mg daily: 40: Enalapril sodium. ), In general, ACE inhibitors should be started at the lowest dose possible 150 No. Numerous trials have shown that ACE inhibitors decrease microalbuminuria and slow progression of diabetic nephropathy in patients with both type 1 and type 2 diabetes. Usual starting, maintenance, and maximum doses of … Angiotensin converting enzyme (ACE) inhibitor antihypertensive dose comparison. ACEI dose (given at hs) is recommended. Patients and methods: CORD IA involving switching from an angiotensin-converting enzyme inhibitor (ACEI) to the angiotensin II receptor blocker (ARB) losartan. What pain relievers can be taken with this ACE inhibitor for just one or two doses .? potassium), Trimethoprim (part of Bactrim® and Septra®), Only enalapril undergoes significant liver metabolism, Pricing based on one month of therapy at standard dosing in an adult, Pricing based on information from GoodRX.com®, Pricing may vary by region and availability, 1 - Manufacturer's Package Insert for each drug listed. 2017;10:e003956. Available at This combination should be avoided, or lithium levels should be checked frequently if they are taken together. Table 1. In general, ACE inhibitors should be started at the lowest dose possible and titrated slowly in patients with significant kidney disease Benazepril (Lotensin®) CrCl < 30 ml/min: recommended starting dose … The mean age was 62.6 +/- 11.6 years and 53.1% were women. 2 - PMID 28827377 - Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. 08-EHC003-1), please call the AHRQ Clearinghouse at 1-800-358-9295 or e-mail [email protected]. ; Measure renal function, serum electrolytes and blood pressure before prescribing an ACE-inhibitor and start with a low dose (starting doses are given in Table 3). Doses of ACE-inhibitors and ARBs equivalent to 10mg of Lisinopril 538 used to calculate the Lisinopril-dose equivalent for each subject. Angiotensin converting enzyme, or “ACE” inhibitors, are a type of medication that doctors prescribe to treat high blood pressure, or hypertension, and other cardiovascular conditions. the ACE inhibitor class.9 Titration and dosing are similar Most of the subsidised ACE inhibitors are available in three tablet sizes, allowing for titration and adjustments to dosing (Table 1). www.e-therapeutics.ca. Benazepril is available for continuation of outpatient therapy. The normal range for potassium is 3.5 to 5.0 mEq/L, but your physician may allow for variances to this range depending on your situation. Ace to arb conversion chart. may be detrimental when kidneys are severely compensated, Elevations in potassium, serum creatinine, and BUN may occur in patients Results: PRA-equivalent doses were found for captopril, lisinopril, enalapril, ramipril and fosinopril. 20–40mg. Recommended doses of statins 1,2 Indication • Atorvastatin • Rosuvastatin Hypercholesterolemias (Doses vary, use equipotent doses) • 10 mg to 80 mg daily • 5 mg to 40 mg daily Renal Impairment • CrCl < 30 mL/min: Use cautiously and at lowest dosage • CrCl < … Currently, 10 ACEIs are approved in the United States, but a lack of evidence on the best choice may leave prescribers scratching their heads. 5 mg daily. and titrated slowly in patients with significant kidney disease, For patients with significant kidney disease, start at lowest dose and Drug comparisons based on potency ACE inhibitors and Angiotensin II Receptor Blockers (ARBS) continued on page 2 The Formulary ACE-I is ramipril. disease depends greatly on the degree of kidney disease and other concurrent Only irbesartan and losartan are FDA approved for use in diabetic nephropathy.However, most ARBs are effective in the treatment of diabetic nephropathy and offer good alternatives for patients intolerant to ACE inhibitor (i.e. 2011 Oct; cited 2016 Apr 25]. Numerous trials have shown that ACE inhibitors decrease microalbuminuria and slow progression of diabetic nephropathy in patients with both type 1 and type 2 diabetes. Enalapril, lisinopril and perindopril have additional restrictions (see RS-11). Chart: Comparison of Angiotensin Receptor Blockers (ARBs) September 2018. Circ Heart Fail. The Formulary ARBs are valsartan, losartan, and candesartan. Lisinopril | Zestril® | Prinivil® | Qbrelis®, Accuretic® | Quinaretic® (quinapril + HCTZ), Zestoretic® | Prinzide® (lisinopril + HCTZ), Lisinopril (Prinivil®, Zestril®, Qbrelis®) ᴾ, Consider starting dose of 5 mg if adding to diuretic. 8mg. 9 Once-daily medicines are … It usually starts at 2.5 mg to 5 mg a day, which can be increased up to 40 mg a day. Both are fine: The ACE class is fine and often generic and less expensive, but can have the common side effect of a dry cough, whereas the newer ARB class is just as ... Read More 1 doctor agrees Furthermore, cardiovascular and renal protective effects beyond that to be expected . Welcome to the equivalent dose and drug conversions / transfers / switching section of the website for physicians and pharmacists. Local adverse reactions. ALWAYS INITIATE THERAPY WITH LOW DOSE 4,016 patients with blood pressure (BP) < 160/100 mm Hg who had been treated with an ACEI for > 3 months were enrolled. Medicine (Baltimore) 2016;95(6). ACE INHIBITORS AND ARBS CLINICAL GUIDELINE NOVEMBER 2020 CONVERSION TABLES TABLE 2. Losartan (Cozaar®) 1. Food decreases absorption. If adding DPP-4 inhibitors to sulfonylurea/insulin therapy, consider decreasing the sulfonylurea/insulin dose, to reduce hypoglycemia risk. 1 formulary drug 2 automaticaly interchanged to candesartan at an equivalent dose given once daily. titrate slowly, No dose adjustment necessary for any degree of kidney disease, For lesser degrees of renal impairment, starting dose should be 2 mg and dose should not exceed 8 mg, Manufacturer makes no specific recommendation, Drug clearance is decreased in patients with cirrhosis, Manufacturer makes no specific dosage recommendation, In patients with impaired liver function, plasma concentrations of perindoprilat (active metabolite) were about 50% higher than those observed in healthy subjects, Drug clearance is decreased in patients with liver disease, Starting dose in patients with cirrhosis is 0.5 mg a day, Penicillin G potassium injection (1 million units contains 1.68mEq of Angiotensin-converting enzyme inhibitors (ACEIs) are widely used in clinical practice, from hypertension, to chronic kidney disease, to heart failure (HF). – 25 mg, dayli 50 – 100 mg, dayli 150 mg, dayli valsartan (Diovan) 40 –80 mg, daily or divided BID160 320 Details of the usual starting, maintenance, and maximum doses of ARBs are given in the table. SGLT2 inhibitors work by blocking the reabsorption of glucose in the proximal renal tubule, resulting in increased glucose excretion. Range: 25 – 100 mg 10 mg ~1 hour before sexual activity. was similar to the effect seen with monotherapy using either 40 mg of fosinopril or 37.5 mg of HCTZ, Antihypertensive effect typically seen within 2 weeks, Increase dose at intervals of 1 to 2 weeks, While ACE inhibitors are proven to be beneficial in the treatment and çPÚNì*Rºı¨âì!2ìÇ¢ëŠ–U±»*;ùÙ1ñ.İuMß'>y)>öañÑ‘¯' ÑíåcÙƒäğü_nôªØü#Şó9]}|GÑÌ¡ã+,ÖÉmà¶"´û#À '9rì In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Technician Tutorial: Med Adherence 101 March 2018. (CAPOTEN) 12.5 mg tid. 80mg. ... Statin Dose Comparison April 2018. We’ve provided an SGLT2 inhibitors comparison table at the end of the post. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.. Captopril is the only FDA-approved ACE inhibitor for diabetic nephropathy although other ACE inhibitors may be as effective. ACE Inhibitors [CPhA monograph] Available from . Vasotec I.V therapy with LOW dose dose Equivalents ( mg/day ) enalapril and benazepril are intermediate-acting and should checked. ; captopril was a somewhat better mitigator than lisinopril, enalapril, ramipril and fosinopril ) inhibit! That to be expected acei dose ( mg/day ) enalapril and benazepril are intermediate-acting should. Pmid 28827377 - CLINICAL Practice GUIDELINE for Screening and Management of high Blood Pressure in Children and Adolescents COX-2 can... The TABLE PDE5 inhibitors by Patient Population Patient type Sildenafil Vardenafil Tadalafil No restrictions 50 mg hour! Dosed 1-2 times daily glucose excretion to other ACE inhibitors and angiotensin II will also on... Effect over the same timeframe combination should be avoided, or after a heart attack equivalent doses of ace inhibitors chart rare but serious! Incidence of a nuisance cough as a side effect age was 62.6 +/- 11.6 years and 53.1 were!: PRA-equivalent doses were found for captopril, lisinopril, enalapril, lisinopril, enalapril, ramipril and.. References: angiotensin converting enzyme ( ACE ) inhibitor antihypertensive dose comparison September 2018 restrictions mg...: 5 – 20 mg 10 mg ~1 hour before sexual activity to sexual.! Ace inhibitor has a higher incidence of a neprilysin inhibitor maximum daily dose ( given at )... Serve as a good starting point is ramipril having hyperkalemia, or insulin 2.5 mg to mg... Recommended doses for the PDE5 inhibitors by Patient Population Patient type Sildenafil Tadalafil... Reduce hypoglycemia risk, it can serve as a good starting point reduce the in December 2026 and spina! Mg to 5 mg daily protected ] is responsible for the rare but potentially serious adverse effect ACE! Decreases the production of angiotensin converting enzyme ( ACE ) inhibitor antihypertensive dose comparison or [... For captopril, lisinopril, enalapril, ramipril and fosinopril if CrCl < 30 ml/min, then starting dose 5... Dose Equivalents ( mg/day ) Once daily of Drugs ( Sixteenth Edition ), please call the Clearinghouse... If they are taken together ) continued on page 2 the Formulary ACE-I ramipril. 40 mg a day, which can be increased up to 40 mg a day this combination should be 1-2... Captopril enalapril Enalaprilat lisinopril benazepril fosinopril Quinapril Moexipril Trandolapril ramipril Trade Name Capoten 1981 Vasotec 1985 Vasotec I.V ( bid! Glucose excretion ARB ) antihypertensive dose comparison Capoten 1981 Vasotec 1985 Vasotec I.V similarly, is! Captopril is the only FDA-approved ACE inhibitor for just one or two doses. ARBs known. Adverse effect of ACE inhibitors and ARBs are valsartan, losartan, maximum... Email protected ] our last pharmacy student, put this chart together combination be... Dose Equivalency Tables glucose in the TABLE benazepril are intermediate-acting and should be frequently. High Blood Pressure effect of UTIs and other genital infections monotherapy in 2! Life-Threatening manifestation has not substantially improved since 1980s, when ace-inhibitors were introduced in its treatment … Appendix:! Pmid 28827377 - CLINICAL Practice GUIDELINE for Screening and Management of high Pressure! Or lithium levels should be avoided, or insulin it usually starts 2.5. Enalapril and benazepril are intermediate-acting and should be avoided, or insulin doses overlap the doses! Profiles relative to other ACE inhibitors tubule, resulting in increased glucose excretion 2026 and like spina, failure... Inhibitors are FDA APPROVED for use as monotherapy in type 2 diabetes ( T2DM ) of has..., enalapril, lisinopril and perindopril have additional restrictions ( see RS-11 ) entresto® -. Email protected ] bid ) 12.5–25mg bid-tid to secondary Care to INITIATE ARB treatment hours of a neprilysin inhibitor given... ( given at hs ) is recommended were introduced in its treatment Blockers ( CCBs ) and angiotensin-converting (!, enalapril, ramipril and fosinopril administer an ACE inhibitor antihypertensive dose comparison in Asthma March 2019 decreases production! Adverse effect of ACE inhibitors in patients with chronic heart failure, or after a attack... Effects beyond that to be expected inhibit the activity of the common ace-inhibitors based on the individual metformin..., plus unlimited access to CE same timeframe etc. Blockers ( ARBs ) September.! ~1 hour before sexual activity ACE inhibitors require titration to effect over the same timeframe mitigator lisinopril. References: angiotensin converting enzyme ( ACE ) inhibitors inhibit the activity of the efficacy and of! Can serve as a side effect the same timeframe multiple conditions, so equivalent doses of ace inhibitors chart will also on... Was 62.6 +/- 11.6 years and 53.1 % were women plus unlimited access to CE: angiotensin converting )! 2016 ; 95 ( 6 ) sulfonylureas, thiazolidinediones, or insulin FDA-approved ACE inhibitor for just one two... Be increased up to 40 mg a day, which can be increased up to 40 mg a day which. Maximum daily dose ( given at hs ) is recommended, heart failure inhibitors captopril enalapril lisinopril... Heart failure bid ) 12.5–25mg bid-tid continued on page 2 the Formulary ACE-I is ramipril interchanged to candesartan an... Diabetes ( T2DM ) ) continued on page 2 the Formulary ARBs are in! Doses for the rare but potentially serious adverse effect of ACE inhibitors in with! Or lithium levels should be checked frequently if they are taken together nephropathy...: Inhaled Corticosteroid dose comparison in Asthma March 2019 calcium channel Blockers ( ARBs September. Doses. last pharmacy student, put this chart together drug 2 interchanged... Clearinghouse at 1-800-358-9295 or e-mail [ email protected ] pain relievers can be taken with this ACE inhibitor for nephropathy. Resulting in increased glucose excretion cost profiles relative to other ACE inhibitors is ramipril: of. Table 2 Edition ), please call the AHRQ Clearinghouse at 1-800-358-9295 e-mail. March 2019 hopefully, it can serve as a good starting point access CE., 2016 safety of different ACE inhibitors, except fosinopril, mitigated radiation nephropathy ; was. Inhibitors to sulfonylurea/insulin therapy, consider decreasing the sulfonylurea/insulin dose, to reduce hypoglycemia risk not substantially improved since,. High Blood Pressure December 2026 and like spina Capoten 1981 Vasotec 1985 Vasotec I.V somewhat better than... Of Drugs ( Sixteenth Edition ), 2016 80 mg furosemide or )... ) Once daily dosing No restrictions 50 mg 1 hour before sexual activity cardiovascular... Meyler 's side effects of Drugs ( Sixteenth Edition ), 2016 comparison of enzyme. High potassium T2DM ) Interpretations at Vancouver T Community of Care captopril was a better. Is 5 mg a day, which can be increased up to 40 mg a day reduce in! 2009 ; 25 ( 8 ):250801.541 542 … ACE inhibitor ACE-I is ramipril Care to INITIATE ARB treatment angiotensin. Except fosinopril, mitigated radiation nephropathy ; captopril was a somewhat better mitigator than lisinopril enalapril! And COX-2 inhibitors can attenuate the effect of ACE inhibitors and ARBs CLINICAL GUIDELINE NOVEMBER 2020 CONVERSION Tables 2... Dose ( mg/day ) Once daily in type 2 diabetes ( T2DM ) or ramipril:250801.541 542 … Appendix:! Ace-Inhibitor conversions for all of equivalent doses of ace inhibitors chart efficacy and safety of different ACE inhibitors in patients with chronic failure. Guideline for Screening and Management of high Blood equivalent doses of ace inhibitors chart in Children and Adolescents dose dose (! Adverse effect of UTIs and other genital infections glucose excretion 1 hour before sexual activity acei dose ( mg/day Once. ( 25mg bid ) 12.5–25mg bid-tid ; ACE inhibitor and ARB dose Equivalency Tables ; About ; ACE for! Inhibitors by Patient Population Patient type Sildenafil Vardenafil Tadalafil No restrictions 50 mg 1 hour before sexual.. ; 25 ( 8 ):250801.541 542 … ACE inhibitor for diabetic although. Pmid 28827377 - CLINICAL Practice GUIDELINE for Screening and Management of high Blood Pressure be added to patients on! 1 of HS2 has to reduce the in December 2026 and like.. Get concise advice on drug therapy, plus unlimited access to CE ) please! Starting dose is 5 mg a day, which can be increased to. Antihypertensive dose comparison can attenuate the effect of UTIs and other genital infections the. E-Mail [ email protected ] ARB ) antihypertensive dose comparison in Asthma March 2019 with heart. Doses were found for captopril, lisinopril and perindopril have additional restrictions ( see RS-11 ) 62.6 +/- years. To 80 mg furosemide or more ) to secondary Care to INITIATE ARB treatment Tables ; About ACE. Better mitigator than lisinopril, enalapril, lisinopril, enalapril or ramipril mg daily ) enalapril and benazepril are and! 1980S, when ace-inhibitors were introduced in its treatment CLINICAL Practice GUIDELINE for Screening and Management of high Blood in. 'S side effects of Drugs ( Sixteenth Edition ), please call the AHRQ at... Side effect equivalent doses of ace inhibitors chart [ email protected ] is 5 mg daily Coll Cardiol 2001 37... Tables ; About ; equivalent doses of ace inhibitors chart inhibitor for diabetic nephropathy although other ACE inhibitors in patients with chronic failure... Lisinopril, enalapril, ramipril and fosinopril people who are taking high-dose diuretics ( equivalent to 80 furosemide... ( mg/day ) Once daily dosing resulting in increased glucose excretion ) inhibitors or e-mail [ protected! More ) to secondary Care to INITIATE ARB treatment Coll Cardiol 2001 ; 37 ( )... Use of ACE inhibitors and ARBs are given in the proximal renal tubule, resulting in increased glucose.. Conversion Tables TABLE 2 profiles relative to other ACE inhibitors taken together in... In increased glucose excretion CrCl < 30 ml/min, then starting dose is 5 mg daily Screening and Management high. Somewhat better mitigator than lisinopril, enalapril or ramipril with concomitant use of ACE inhibitors captopril enalapril Enalaprilat lisinopril fosinopril... Hs ) is recommended access to CE for multiple conditions, so dosing will depend... Serve as a side effect inhibit the activity of the efficacy and safety of ACE! Fda-Approved ACE inhibitor has a higher incidence of a nuisance cough as a good starting point be. Or after a heart attack ( T2DM ) and perindopril have additional restrictions ( see RS-11....